INS and metabolic dysfunction-associated steatotic liver disease: With the regulation of insulin, extra glucose is normally stored as glycogen, or it can be esterified to TAG or VLDL via the DNL process.84, 85 In contrast, with glucose, which is highly regulated by insulin, almost all fructose can be transformed into FAs via DNL,86 which is precisely why high‐fructose diets can easily induce NAFLD.