Plentiful of studies have approved that hepatic fat is strongly inheritable based on genetic and epidemiological methods.172 With the development of GWAS, the genetic factors linked to the progression and outcomes of NAFLD have become better known and have provided new possibilities for both the pathogenesis of and therapeutics of NAFLD.20, 21, 173, 174, 175 The best‐known candidate genes are PNPLA3 (patatin‐like phospholipase domain‐containing protein 3) and TM6SF2 (transmembrane 6 superfamily member 2). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.