Using an antibody enzyme‐linked immunosorbent assay (ELISA), serum CK18 levels can be measured sensitively; however, their clinical application is premature.26, 49 Inflammation is also a histological hallmark of NASH, and many inflammatory markers and mediators could serve as biomarkers of NASH, including tumor necrosis factor (TNF), interleukin‐6 (IL‐6), IL‐8, and C‐reactive protein (CRP). This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.