According to the pathogenesis of liver injury in NASH, specific serum biomarkers can be used to diagnose NASH.55, 56 Hepatocyte death occurs via apoptosis or necroptosis increasing in NASH, resulting in the release of cytokeratin 18 (CK18), a type of intermediate filament protein. The gene discussed is KRT18; the disease is metabolic dysfunction-associated steatohepatitis.