NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases; FXR, farnesoid X receptors; PPAR, peroxisome proliferator‐activated receptors; SCD‐1, stearoyl‐CoA desaturase‐1; ACC, acetyl‐CoA carboxylase; GLP, glucagonlike peptide; LPS, lipopolysaccharide; PDE, phosphodiesterase; CCR, C‐C chemokine receptor; ASK1, apoptosis signal‐regulating kinase 1; LOXL2, lysil oxidase homologue 2. The gene discussed is PPARA; the disease is diabetes mellitus.