In the TP53 wild-type samples (n = 28), the PI3K pathway appeared to be a predominant driver with 19 samples (68%) containing a mutation in either the PIK3CA gene or PI3K pathway members, including PIK3C2B, PIK3CG and PTEN. In the TP53 mutant group, 67 samples (76%) had one or more mutations in genes encoding chromatin remodeling proteins, including ATRX, DNMT3A and KMT2C, which have been reported to be involved in cancer. This evidence concerns the gene PIK3C2B and cancer.