Compared to the cancer gene mutation frequencies from TCGA, METABRIC and French cohorts, Thai TNBC had significantly higher mutation frequencies in KMT2C, SYNE1, PIK3CA, NF1, PTEN, BRCA1 and BRCA2. On the contrary, significant differences were observed only in SYNE1 and BRCA1 among TCGA, METABRIC and French cohorts. The gene discussed is PIK3CA; the disease is cancer.