Seregin and his colleagues found that NLRP6, which is a member of Nod-like receptor (NLR) family and are involved in the formation of inflammasomes [43], its deficiency can increase the susceptibility to DSS-induced colitis [44] and induced the enrichment of Akkermansia muciniphila that could function as a pathobiont by promoting colitis in a genetically-susceptible host [45]. Here, NLRP6 is linked to colitis.