Stimulation with 2GF + TNF caused the cells to remain in a pPDGFRαβ-predominant state, similar to the pPDGFRαβ+CDH11– cells observed in RA-SL, which indicates that therapies that are effective against these cells could lead to treatments for cells accumulated in the synovium. The gene discussed is TNF; the disease is rheumatoid arthritis.