In this regard, IL-13Rα2-CAR T cells modified to secrete IL-15 (IL-13Rα2.IL-15-CAR) demonstrated superior proliferative capacity and antitumor activity in vitro and in vivo against high grade glioma compared to IL-13Rα2-CAR alone (35). The gene discussed is IL13RA2; the disease is central nervous system cancer.