When Ahmad and colleagues induced overexpression of p53 in human prostate cancer cells and combined it with treatment with 2-deoxy-D-glucose, they showed that the cancer cells overexpressing p53 died of oxidative stress by disrupting glucose influx using 2-deoxy-D-glucose, demonstrating a major role for p53 in glucose metabolism major metabolic switch (38). This evidence concerns the gene TP53 and prostate cancer.