In the stroma, both tumor cells and these abundant M2 TAMs secrete various molecules, such as vascular endothelial growth factor (VEGF), interleukin (IL)-10, transforming growth factor (TGF)-β, adenosine, and prostaglandin E2, that inhibit DC activation and maturation and suppress the activity of CTLs and natural killer-mediated immunity (17). This evidence concerns the gene TGFB1 and neoplasm.