Gene expression profiling performed with a series of melanoma metastases identified six chemokines—CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10—that are associated with CD8+ T-cell recruitment and demonstrated that chemokine blockade inhibited migration of CD8+ effector T cells in vivo (8). This evidence concerns the gene CD8A and melanoma.