In particular, oral supplementation with B. coagulans 09.712 and L. plantarum 08.923 significantly ameliorates anaphylaxis symptoms and increases the population of CD4+ CD25+FoxP3+ T cells through mTORC inhibition, FoxP3 upregulation, and GATA-3 downregulation (145). Here, CD4 is linked to anaphylaxis.