Pasireotide, a new synthetic SST analog active on SSTR1-3 and SSTR5 (Weckbecker et al., 2003), induces apoptosis in malignant PC-derived cells and potentiates the antineoplastic effects of prednisone and docetaxel in phase I clinical trial (Lo Nigro et al., 2008; Erten et al., 2009; Thakur et al., 2018). This evidence concerns the gene SSTR1 and pachyonychia congenita.