Human DAT mutations associated with DAT misfolding and degradation have been recently described as causes for the hereditary DTDS (Kurian et al., 2009, 2011; Ng et al., 2014; Beerepoot et al., 2016; Kasture et al., 2016). The gene discussed is SLC6A3; the disease is SLC6A3-related dopamine transporter deficiency syndrome.