As shown in Table 1, high miR-96 expression and low FOXO1 protein expression was dramatically associated with positive lymph node metastasis and infiltration, and low-medium differentiation (P < 0.05), suggesting that miR-96 up-regulation and FOXO1 down-regulation predicted poor prognosis in HCC patients. The gene discussed is FOXO1; the disease is hepatocellular carcinoma.