This resulted in a change in clinicopathological staging in 22 cases.Correlation between the postoperative CK20 mRNA expression in lymph nodes andclinicopathological factors was closely related to the degree of differentiation(P = 3.19 × 10−4), invasive depth (P =4.188 × 10−5), microvessel invasion (P = 1.673 ×10−4), the tumor diameter (P = .019), Borrmann type(P = .049), tumor-related antigens including CEA (P =.034), CA724 (P = .008), and CA199 (P = .037), as wellas preoperative (P = .024) and postoperative CK20 expression inperipheral blood (P = .004). Here, KRT20 is linked to neoplasm.