Further studies have shown that POLE and POLD1 mutations predispose individuals to multiple adenomas and early‐onset CRC (Bellido et al., 2016; Chubb et al., 2015; Elsayed et al., 2015; Esteban‐Jurado et al., 2017; Rohlin et al., 2016; Spier et al., 2015; Valle et al., 2014). This evidence concerns the gene POLE and colorectal carcinoma.