nAMD is the leading cause of blindness in the western world, and the disease is currently treated by repetitive, often monthly intraocular injections of anti-vascular endothelial growth factor (VEGF) drugs (e.g., antibodies or traps) to maintain vision.24, 25, 26 However, nAMD is a complex and multifactorial disease caused by multiple genetic and environmental factors, and it is characterized by progressive degeneration of the outer retinal layers.27, 28 This stimulates neovascularization from the choroid into the sub-RPE space and the retina to disrupt the normal retinal anatomy. The gene discussed is VEGFA; the disease is blindness (disorder).