Similarly, Zadeh and colleagues54 found Angpt-1 expression to be significantly diminished in a tumor angiogenesis model, following the downregulation of VEGFA. Even though we cannot formally rule out that injection of the control AAV vector (AAV/miR(Irr)-AsR-PE) might have some impact, the data strongly suggest that our anti-VEGF therapy affects other players in the angiogenic pathway, following reduced VEGFA expression. This evidence concerns the gene VEGFA and neoplasm.