Here, we use a multi-omics approach to demonstrate that protein tyrosine phosphatase, receptor type, f polypeptide, leukocyte common antigen (LAR) interacting protein (liprin), alpha 1 (PPFIA1) is a direct target for miR-181a in CML. The gene discussed is PTPRC; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.