PPFIA1 is a member of the liprin family, and its encoding gene maps to the 11q13 amplification region,15 which is one of the most common amplicons in multiple epithelial cancers, including breast cancers,16 head and neck squamous cell carcinomas (HNSCCs),17 and oral squamous cell carcinomas (OSCC).18 Here, PPFIA1 is linked to head and neck squamous cell carcinoma.