Several recent study demonstrated thatMVs which are derived from LAMA84 CML cell linethrough secretion of interleukin-8 (IL-8) can induce theintercellular adhesion molecule 1 (ICAM-1) and vascularcell adhesion molecule 1 (VCAM-1) expression in humanumbilical vein endothelial cells (HUVECs), which isassociated with an increase in the adhesion and migrationof CML cells (4, 11, 55, 56). Here, VCAM1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.