Elevated levels of some MVs CDmarkers expression such as CD52 can be associatedwith the CLL progression toward advanced stage (33).Similarly, a higher expression of myeloid progenitorCD markers in AML MVs may display the presence ofthe active myeloid neoplastic clone in BM (11, 40, 47).Hence, flow cytometry analysis of MVs related to CDmarkers in alongside the specific diagnostic CD markersin leukemias can reveal their prognostic value in diseaseprogression. This evidence concerns the gene CD52 and B-cell chronic lymphocytic leukemia.