It hasbeen shown that the reduced expression of these miRscan be associated with the increased expression ofa number of genes such as cyclin D1 (CCND1) andB-Cell CLL/Lymphoma 9 (BCL9) in this cell line (16).BCL9 is a component of the Wnt/ß-catenin signallingpathway that plays an important role in the regulationof self-renewal, proliferation, and differentiation innormal and malignant cells. This evidence concerns the gene BCL9 and B-cell chronic lymphocytic leukemia.