Considering the fact thatICAM-1 and VCAM-1 can mediate CML cells adhesionto endothelial cells, it may be similar to LAMA84 CMLcell line, the release of IL-8 from MVs-derived CML caninduce thrombotic process in this malignancy. The gene discussed is VCAM1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.