Studies displayed thatin addition of the genetic background of individuals,some AML MVs contain proteins that play a crucialrole in drug resistance and relapse in this disease (52).AML MVs contain chemoattractants such as I-309,monocyte chemotactic protein 1 (MCP-1), and MCP4,which can lead to the resistance of AML blasts tochemotherapy by trafficking, proliferation, migration,and mobilization of these blasts (52, 53). The gene discussed is CCL13; the disease is acute myeloid leukemia.