Several recent study demonstrated thatMVs which are derived from LAMA84 CML cell linethrough secretion of interleukin-8 (IL-8) can induce theintercellular adhesion molecule 1 (ICAM-1) and vascularcell adhesion molecule 1 (VCAM-1) expression in humanumbilical vein endothelial cells (HUVECs), which isassociated with an increase in the adhesion and migrationof CML cells (4, 11, 55, 56). The gene discussed is CXCL8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.