C reactive protein ≥90 mg/L, hypotension, platelet number ≤50 000 /mm3, relapsed leukemia, and chemotherapy in the last 7 days were shown to be the predictors for severe bacterial infection (19), while intensive chemotherapy, shorter time-to-diagnosis, presence of CVC and previous FN were shown to be predictors for development of FN and FN with bacteremia (20). The gene discussed is CRP; the disease is bacterial infectious disease.