C reactive protein ≥90 mg/L, hypotension, platelet number ≤50 000 /mm3, relapsed leukemia, and chemotherapy in the last 7 days were shown to be the predictors for severe bacterial infection (19), while intensive chemotherapy, shorter time-to-diagnosis, presence of CVC and previous FN were shown to be predictors for development of FN and FN with bacteremia (20). This evidence concerns the gene CRP and bacterial infectious disease with sepsis.