ZEB2 protein might have a tumor promoter role because it controls cell cycle progression and cell differentiation.26 Wang et al found that E2F1 promoted EMT by modulating the promoter region of ZEB2 in NSCLC.27 ZEB2 is a transcription factor that participates in adjusting different biological activities, including the inhibition of apoptosis of vascular endothelial cells via the MAPK pathway activation.28 Meanwhile, the mechanisms by which lncRNA‐ZEB2‐AS1 regulates EMT in breast cancer remain unknown. Here, E2F1 is linked to non-small cell lung carcinoma.