IL6 and neoplasm: Acid-induced NF-κB activation downstream promotes the secretion of several cytokines, chemokines, and growth factors (IL1a, IL1b, IL6, IL8, IL23a, CCL5, CCL7, CXCL2, GM-CSF, and G-CSF) [125] that can elicit local cancer aggressiveness, tumor immune escape, and tumor-induced nociception and hyperalgesia.