CRP and synovitis: The objectives of the current study were firstly to confirm whether TJC28, SJC28, CRP, ESR and GHVAS are independently associated with imaging-detected synovitis, using US combined grey scale and power Doppler (GSPD) score as the outcome; and secondly to define a novel re-weighted DAS28 using appropriate components, and validate it against radiographic progression in an external cohort.