TLR3 and neoplasm: In our study, we established a simple selective delivery system for TLR3 agonists to tumor cells using a recently described modular bio-conjugation system comprising neutravidin, mono-biotinylated single chain fragment variables (scFv) and mono-biotinylated TLR3 agonist Riboxxol-biotin, which belongs to a type of serum-stable dsRNA14.