CRC remained as an independent predictor of HCC development in multivariate analysis (HR, 5.48; 95% CI, 1.63–18.36; P = 0.006), along with liver cirrhosis (HR, 3.23; 95% CI, 1.22–8.63; P = 0.018), AFP level > 10 ng/mL (HR, 4.26; 95% CI, 1.41–12.85; P = 0.010), and platelet count < 125×109/L (HR, 5.76; 95% CI, 2.19–15.11; P < 0.001). The gene discussed is AFP; the disease is hepatocellular carcinoma.