To investigate the involvement of TAMM41 in CHD development, 118 unrelated CHD patients of Han Chinese ancestry (diagnosed as simple AVSD or complex AVSD accompanied with more complex heart abnormalities) were enrolled (Supplemental Table 1) and all candidate genes located within the congenital heart diseases (CHD) sensitive region of 3p25 deletion syndrome were sequenced. This evidence concerns the gene TAMM41 and coronary artery disorder.