PTTG1 and dedifferentiated liposarcoma: Accordingly, the β-catenin target genes BIRC5 and PTTG1 were downregulated more than 50% in miR-193b or YAP1 siRNA-treated DDLS and WDLS cells (Fig. 5g), suggesting that miR-193b regulates Wnt/β-catenin signaling by inhibiting the Hippo regulator YAP1 in WDLS/DDLS cells.