In the current study, we report three new signaling pathways (PDGFR, TGFβ, and Wnt) targeted by miR-193b in liposarcoma, which could contribute to miR-193b’s functions as a tumor suppressor by inhibiting proliferation and promoting adipogenic differentiation in WDLS cells and adipose-derived stem cells (ASCs). This evidence concerns the gene TGFB1 and liposarcoma.