The fact that knockdown of YAP1 induced apoptosis in WDLS but not DDLS cells (Fig. 5e), but ICG-001 induced apoptosis in both WDLS cells and DDLS cells (Figs 5i and S5) suggests that YAP1 may affect Wnt/β-catenin signaling differently in WDLS vs. DDLS cells due to their different biological backgrounds. Here, YAP1 is linked to dedifferentiated liposarcoma.