We recently reported that miR-193b functions as a tumor suppressor in liposarcoma by targeting the FAK-SRC-CRKL axis12, and here, we identify three novel targets of miR-193b (PDGFRβ, SMAD4, and YAP1), which respectively play key roles in PDGFR, TGFβ, and Hippo/Wnt signaling. Here, SMAD4 is linked to liposarcoma.