TLR4 and Miyoshi myopathy: Notably, treatment of MM cell lines with medium or high TLR4 levels, (H929 and JJN3, respectively) with the TLR4 inhibitor alone (0.1, 0.5, 1, 5 and 10 μg/ml concentrations), significantly inhibited their viability dose-dependently by up to 40% (Fig. 2e) indicating that at least with medium/high TLR4 expression levels basal TLR4 signaling contributes to MM cell viability in the absence of LPS induction.