In our study, the magnitude of the difference in body weight between mice with adipose tissue-specific Lepr reconstitution (AdipoqCre+LeprloxTB/loxTB) and loxTB control mice (AdipoqCre−LeprloxTB/loxTB) was similar, ~6 g at 16 weeks of age, but Lepr reconstitution did not reduce obesity in our study. This evidence concerns the gene LEPR and obesity due to melanocortin 4 receptor deficiency.