In line with increased T-SCE frequency in NONO/SFPQ-depleted cells we observed an increased frequency of co-localization of TRF2 with Promyelocytic Leukemia (PML) nuclear bodies and co-localization of RAD51 with TRF2 in U-2 OS cells that were depleted for SFPQ (Fig. 5g–j). Here, TERF2 is linked to leukemia.