In line with this, immunoprecipitation experiments using extracts from telomerase-positive H1299 and telomerase-negative U-2 OS osteosarcoma cells that maintain telomeres via the recombination-based “alternative lengthening of telomeres” (ALT) pathway, confirm a direct interaction between NONO and SFPQ in the cell model systems used in this study (Supplementary Figure 1A, B). The gene discussed is GPT; the disease is osteosarcoma.