A multivariate analysis of these GBM patient survivals was carried out based on IHC score of 6PGD Y481 phosphorylation and IDH1 R132H mutation, which suggested that either 6PGD Y481 phosphorylation or IDH1 R132H mutation could be an independent predictor of GBM patient survival (Fig. 6c). This evidence concerns the gene IDH1 and glioblastoma.