The plasma levels of three proteins that are involved in the acute phase reaction increased strongly upon progression from mild to severe NAFLD: Saa1 (serum amyloid A‐1 protein) by 3,250%, Apcs (serum amyloid P‐component) by 440%, and Orm2 (alpha‐1‐acid glycoprotein 2) by 270% (Fig 5G–I). Here, APCS is linked to metabolic dysfunction-associated steatotic liver disease.