Interestingly, along with Dpp4, two other aminopeptidases—Lap3 (leucine aminopeptidase 3) and Enpep (glutamyl aminopeptidase)—also increased in severe NAFLD compared to mild NAFLD, by 273 and 327%, respectively, followed by a decrease upon treatment (Fig 5K and L). This evidence concerns the gene ENPEP and metabolic dysfunction-associated steatotic liver disease.