In fact, the entire regulatory axis could be valuable in CRC-targetted therapy: lncRNA UCA1 is also up-regulated in CRC and involved in cellular migration, its expression correlates with that of both TFAP2A and TFAP2C, and its dependence relies on the occurrence of TF-binding sites (TFBSs) that are located upstream of the start site of UCA1 transcription [65]. Here, TF is linked to colorectal carcinoma.