Autoantibodies to myelin oligodendrocyte glycoprotein (MOG) are associated with a relatively stereotyped set of clinical presentations including recurrent optic neuritis, acute disseminated encephalomyelitis, pediatric acquired demyelinating syndrome, and NMOSD without AQP4 autoantibodies (7–13). The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.