Moreover, in the context of two SLE patients that were found to be positive for AQP4 or AChR autoantibodies, it is interesting to note that AQP4 autoantibody–positive NMOSD can coincide with AChR MG without the presence of SLE, pointing toward possible common pathogenetic elements between these two autoantibody-mediated diseases (49, 50). This evidence concerns the gene AQP4 and systemic lupus erythematosus.