Screening cell-based immunofluorescence assays revealed a higher frequency of MOG and MuSK autoantibody-positive samples compared with AChR or AQP4 (a total of 12/643 [1.9%], 8/643 [1.2%], 5/643 [0.8%], and 4/643 [0.6%] positive samples in the nonneurologic autoimmunity cohorts, respectively). This evidence concerns the gene AQP4 and Autoimmunity.