Choi et al. have reported that the combined inhibition of EGFR and IGF1R signaling pathways could induce the cell cycle arrest in NSCLC cell lines probably due to the EGFR pathway activated by IGF1R-mediated AKT bypass activation, which might lead to the primary resistance in NSCLC cell lines [29]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.