INS and thyroid cancer: In addition to EGF, other growth factors and ligands, such as insulin, lysophosphatidic acid or ATP, modulate the endogenous GroPIns4P level by activating cPLA2α [6], while the level of GroPIns are modulated, for example, by the Fc receptor-dependent stimulation of cPLA2α in macrophages [7], or the Ret/PTC oncogene-dependent PLA2 activation in human thyroid cancer cells [66].