Tumors #1, 3–5 demonstrated a high mutational load yielding mutations in some of the most commonly affected genes in lymphomas (TP53, ATM, KMT2D, STAT3, PAX5, CREBBP, CARD11) [18] (Tables 2, 3, Fig. 4; Additional file 1: section 4 – complete list of mutations). This evidence concerns the gene STAT3 and lymphoma.