Similar to the observation in hepatocellular carcinoma [13], pancreatic cancer [21] and gastric cancer [17], we found that miR-1271 reduced the expression of vimentin and N-cadherin and induced the expression of E-cadherin in breast cancer cells, whereas depletion of endogenous miR-1271 by its inhibitors yielded the opposite effects, suggesting that miR-1271 is an EMT suppressor in breast cancer. This evidence concerns the gene CDH2 and familial pancreatic carcinoma.