SMC1A and cancer: In fact, the overexpression of SMC1A reduced the latency period of cancer formation, and both the size and volume of tumors in a subcutaneous murine xenograft model were significantly increased in presence of up-regulated SMC1A. Of note, tumors induced by SMC1A c.A2027G mutation were bigger than those induced by SMC1A overexpression alone, indicating that mutation has an additive positive effect on tumor growth.