As glomerulosclerosis develops by 4 weeks in CKD models and tubulointerstitial fibrosis develops by 8 weeks [38], we estimate that functioning tubules increase their expression of GLP-1R over the first 2 weeks, followed by decreased expression by week 8 as a result of tubular fibrosis and apoptosis. This evidence concerns the gene GLP1R and glomerulosclerosis.