In patients with AMI, concentrations of PMPs expressing platelet activation markers CD40 ligand (CD154) and P-selectin (CD62P), as well as EMPs expressing markers of endothelial activation E-selectin (CD62E) were significantly higher in patients with severe CKD, compared with CKD 3 and normal kidney function patients, when adjusting for diabetes mellitus prevalence. The gene discussed is CD40LG; the disease is chronic kidney disease.