GJA1 and glioblastoma: Thus, Cx43 was recently discussed to act as a marker for the prognosis of disease progression and survival [83], particularly as Cx43 expression was shown to differ between therapy-responsive versus therapy-resistant tumors: Munoz et al. showed a significant upregulation of Cx43 mRNA and protein in cells from glioblastoma multiforme patients with resistance to the front-line chemotherapy, temozolomide, as compared to cells from a naïve patient (with temozolomide-sensitive glioblastoma) [84].