TNF and periodontitis: “Several mechanisms have been proposed to explain or support such theories, and oral lesions are indicators of disease progression, and oral cavity can be a window to overall health and body systems [156].” Chronic periodontitis is responsible for producing C-reactive proteins (CRP), interleukin-1b (1L-1b), interleukin-6 (1L-6), and Tumor Necrosis Factor-alpha (TNF-α) and disseminate these inflammatory mediator substances through the human body [158,159].