AKT1 and Familial prostate cancer: Apigenin decreased the expression levels of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphatidylinositol 3-kinase (PI3K), proteinkinase B (PKB/Akt), in androgen-negative prostate cancer cells and in CD44+ cancer stem cells isolated from the same cell lines [82].