Polyphenols act as chemopreventive agents in prostate cancer due to their antioxidant or pro-oxidant effects (through reduction of ROS, increasing antioxidant enzyme activity, or inducing cytotoxicity), modulation of androgen receptors (inhibition of expression and function) or their transactivation of signaling pathways (PI3K, Akt, ERK1/2, FoxO, GSK-3β, RTK, etc). This evidence concerns the gene AKT1 and Familial prostate cancer.