Some metabolites of polyphenols play an important role in the protection against prostate cancer and act as antitumor agents through various mechanisms such as cell cycle arrest, inhibition of angiogenesis, downregulation of PSA levels, selective activation of ERβ prostate receptors, suppression of androgen receptor signaling, induction of apoptosis, or anti-inflammatory effects. Here, ESR2 is linked to Familial prostate cancer.