Curcumin reduced the levels of chemotactic cytokines CXCL-1 and -2, cyclooxygenase (COX), secreted protein acidic and cysteine-rich (SPARC)/osteonectin and EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP) proteins in PC-3 prostate cancer cells [119]. This evidence concerns the gene SPARC and Familial prostate cancer.