PTEN and Familial prostate cancer: Resveratrol lowered PI3K, Akt, and glycogen synthase kinase-3 (GSK-3) activities in androgen-dependent prostate cancer cells [108] and reduced the total and phosphorylated levels of PI3K, Akt, and phosphatase and tensin homolog (PTEN) in both androgen-positive and -negative prostate cancer cells [118].