Quercetin inhibited VEGF secretion in PC-3 prostate cancer cells through the activation of the AKT/mTOR/ribosomal protein S6 kinase (p70-S6K) pathway; in addition, in the same set of experiments quercetin inhibited tube formation of the human umbilical vein endothelial cells (HUVEC) cells in parallel with reduced phosphorylation of p-VEGFR2 (Tyr1175) [172]. The gene discussed is AKT1; the disease is Familial prostate cancer.