Dickkopf-1 (Dkk-1)-mediated Wnt pathway inhibition and Wnt pathway ablation are detrimental for crypt fission both in vitro and in vivo [135,136], and increased activation of the pathway (i.e., high β-catenin levels) and impaired cell-cell adhesion (i.e., high β-catenin levels and low E-cadherin) can trigger cancer formation [137,138]. The gene discussed is CDH1; the disease is cancer.