Figure 5A,B). Compared with the normal control group, both fibronectin and collagen I protein were abundant expressed in the diabetic nephropathy group, but markedly reduced in ergosterol-supplemented diabetic nephropathy mice (Figure 5A). Similarly, RT-PCR data shows that the relative mRNA expression of fibronectin and collagen I was reduced in ergosterol-treated diabetic mice (Figure 5B). The gene discussed is FN1; the disease is diabetic kidney disease.