Furthermore, while studies of some chromatin modifiers, such as SIRT6, and the characterization of some telomere-linked diseases, such as FSHD, indicate a key role for chromatin organization and histone modifications in preventing the accumulation of telomere-linked defects, there are relatively few defined links between chromatin regulation and pathologies associated with abnormal telomere function. This evidence concerns the gene SIRT6 and facioscapulohumeral muscular dystrophy.