Our recent studies indicated that the PGC-1α–related pathway may enhance mitochondrial proteins UCP2 and superoxide dismutase 2 to counteract excessive reactive oxygen species (ROS) and increase mitochondrial biogenesis in the hippocampus after cerebral ischemia [44,45,46] and experimental status epilepticus [5,43]. Here, PPARGC1A is linked to brain ischemia.