With a clinically related animal model of status epilepticus, the present study shows changes of mitochondrial biogenesis machinery induced by sustained epileptic seizures that upregulated PGC-1α expression, and resveratrol, the activator of PGC-1α, was accompanied by increased PGC-1α expression and promotion of mitochondrial biogenesis. This evidence concerns the gene PPARGC1A and status epilepticus.