CD8A and neoplasm: The current retrospective comparative study that examined SND (I–III) and MRND/RND confirmed that only SND (I–III) with (4 patients) or without (31 patients) adjuvant radiotherapy for OSCC with pN+ that were limited to levels I and II was appropriate for patients with up to 2 tumor-positive lymph nodes with a largest tumor diameter of ≤3 cm rather than the immunohistochemical invasive tumor patterns or density of tumor–infiltrating CD8+ T cells.