PLOD1 and hypogonadotropic hypogonadism: AN patients present functional hypogonadotropic hypogonadism including low levels of gonadal hormones (estradiol/testosterone), prepubertal patterns of gonadotropin hormones (Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), reduced GnRH pulsatility with menstrual disorders in women, and fertility and sexuality disorders in both sexes [149]), although the literature on endocrinopathies among AN males is sparse [158].