SGCZ and aneurysm: Although none of the SNPs reached a genome-wide significance threshold for IA rupture, one intron variant, the rs6990241 of the SGCZ gene (8p22), showed a suggestive association with aneurysm rupture (OR = 0.34, 95% CI 0.22-0.55; p = 8.5 × 10−6) (Supplementary Figure S1).