In some cases, the blockage of the CD73-adenosine pathway obviously improves the antitumor effect of anti-CTLA4 and anti-PD-1 antibody therapies in metastatic 4T1.2 tumor-bearing mice, which is dependent on host IFN-γ and CD8+ T cells while independent of CD4+ T cells [8,9]. Here, NT5E is linked to neoplasm.