Cyanidin-3-glucoside, one of the most prevalent anthocyanins existing in our diet, ameliorates hyperglycemia and insulin sensitivity via the activation of AMPK in KK-Ay mouse [140], and this activation is accompanied by the up-regulation of GLUT4 in skeletal muscle and the downregulation of gluconeogenesis in the liver. Here, INS is linked to Hyperglycemia.