AKR1B1 and diabetes mellitus: Traditional Chinese medicines and their natural active ingredients have a variety of hypoglycemic effects and effectively control and delay the development of diabetes and complications by scavenging oxygen free radicals, improving blood hypercoagulability, inhibiting protein non-enzymatic glycation, inhibiting aldose reductase, correcting fat and protein metabolism disorders, and inhibiting platelet aggregation [27,28,29,30,31].