INS and obesity due to melanocortin 4 receptor deficiency: Increasing research results show ginseng and ginsenoside Rb1 possess anti-obesity [71], anti-hyperglycemic [72,73], insulin-sensitizing [74], and anti-diabetic properties [75,76], which may be mainly realized by improving glucose tolerance, reducing hepatic fat accumulation [59,64], increasing the sensitivity of insulin, exhibiting adjuvant treatment, suppressing adipocyte lipolysis [77], and regulating adipocyte development and functions [64,73,75].