The increased prevalence of DM, especially type 2 diabetes (T2DM) [1,2,3], is a multi-factor disease resulting from both genetic factors, such as obesity, impaired postprandial insulin secretion, and partial pancreatic ß-cell damage, and environmental factors, including obesity, unhealthy dietary patterns, lack of exercise, and aging [4]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.