AKR1B1 and diabetes mellitus: Obviously, ginsenoside Rb1, a promising natural hypoglycemic agent, has a variety of hypoglycemic effects and can effectively control and delay the development of diabetes (Figure 2) and diabetic complications (Figure 3) through scavenging oxygen free radicals, inhibiting protein non-enzymatic glycation, inhibiting aldose reductase, correcting fat and protein metabolism disorders, inhibiting platelet aggregation, increasing insulin sensitivity, and alleviating the occurrence of T2DM-related complications via multiple links across regulatory mechanisms and multi-target effects.